[English lub npe]: 2-Thiobenzyl nicotinic acid
[CAS Nr.]: 112811-90-2
[Cov ntsiab lus tseem ceeb]: 99.0%min
[Structural formula]:
| Melting point | 188-190 degree |
| Boiling point | 431.1 ± 4 0.0 degree (Predicted) |
| Qhov ntom | 1.33 ± 0.1 g / cm3 (Tshaj tawm) |
| Cia tej yam kev mob | 2-8 degree |
| Daim ntawv | hmoov rau siv lead ua |
| Acidity coefficient (pKa) | 1.56 ± 0.36 (Tshaj tawm) |
| Xim | Dawb mus Yuav luag dawb |
2-Thiobenzyl nicotinic acid yog cov khoom siv hluavtaws uas inhibits kev loj hlob ntawm cov kab mob los ntawm kev khi rau 50S ribosomal subunit. Nws yog siv nyob rau hauv kev kho mob ntawm tuberculosis. 2-Thiobenzyl nicotinic acid yog synthesized los ntawm 2-chloronicotinic acid, uas yog npaj los ntawm reacting benzyl chloride thiab hydrazine. Cov txheej txheem synthesis tuaj yeem muab faib ua ob kauj ruam: ua ntej, benzyl chloride reacts nrog hydrazine los ua ib qho nruab nrab, uas dhau los ua cov kua qaub-catalyzed hydrolysis los tsim 2-chloronicotinic acid; thib ob, lub 2-chloronicotinic acid reacts nrog thiourea los ua 2-thiobenzyl nicotinic acid. Nws tau pom tias qhov sib xyaw no inhibits fungal thiab kab mob loj hlob ntawm qhov siab ntawm 10 μM lossis tsawg dua.
Cim npe nrov: cas:112811-90-2|2-thiobenzyl nicotinic acid, Tuam Tshoj cas:112811-90-2|2-thiobenzyl nicotinic acid manufacturers, hoobkas
