CAS: 145901-11-7|6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE

Kev taw qhia thiab kev siv CAS:145901-11-7|6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE

Siv 7-azaindole ua cov khoom pib, 1H-pyrrole[2,3-B]pyridin-6-amine[1] tau npaj los ntawm bromination thiab cov tshuaj tiv thaiv nrog kua ammonia. Cov tshuaj tiv thaiv synthesis yog raws li nram no:

Daim duab 1 Synthesis cov tshuaj tiv thaiv mis ntawm 1H-pyrrole[2,3-B]pyridin-6-amine

Add 7-azaindole to 10 mL of methylene chloride, slowly add 4.2 mL of glacial acetic acid dropwise at 0°C, and stir for 20 min. Then dissolve the liquid bromine in 20 mL of methylene chloride, then add it dropwise into the reaction system, and react at 0°C for 2 hours. The reaction progress was tracked and detected by thin layer chromatography, and the reaction was stopped when no reactant was found. TLC detection (methanol developing agent) showed that the product Rf=0.57. After the reaction is completed, add saturated sodium sulfite aqueous solution to the reaction system until the starch KI test paper does not change blue. Concentrate the methylene chloride, add 20 mL of water, and adjust the pH to pH>13 los ntawm kev ntxiv NaOH ntawm 0 degree . Tuav cov tshuaj tiv thaiv cov kuab tshuaj kom qhuav, yaj nws nrog methylene chloride, thiab ntxuav nws ob zaug nrog dej huv. Cov theem organic yog qhuav nrog anhydrous sodium sulfate, thiab cov sib tov yog cais los ntawm silica gel kem chromatography, thiab qhuav cov khoom nyob rau hauv lub tshuab nqus tsev vacuum kom tau 1H-pyrrole[2,3-B]pyridine-6-bromide.

Ntxiv 1H-pyrrole[2,3-B]pyridine-6-bromide thiab kua ammonia nyob rau hauv ib qho kev faib ua feem rau plaub-caj dab puag ncig hauv qab lub raj mis nruab nrog ib tug sib nqus stirrer, tus pas ntsuas kub thiab ib tug reflux condenser dej separator , thiab tom qab ntawd ntxiv qhov kub ntawm Petroleum ether ntawm 60 ~ 90 degree, cov tshuaj tiv thaiv yog nqa tawm hauv kev tiv thaiv nitrogen. Taug qab thiab tshawb xyuas qhov kev nce qib ntawm cov tshuaj tiv thaiv nrog nyias txheej chromatography. Nres cov tshuaj tiv thaiv thaum tsis pom cov reactants. Txav qhov sib tov mus rau lub raj mis lim thiab ua lub tshuab nqus tsev distillation ntawm 40 ~ 70 degree kom tshem tawm cov amines qis thiab cov kuab tshuaj kom tau 1H-pyrrole. [2,{14}}B]pyridin-6-amine.

Specification of CAS:145901-11-7|6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE

Melting point 126.7 degree
Kub taw tes 469.5 ± 28. 0 degree (Predicted)
Qhov ceev 1.41 ± 0.1g/cm3 (Predicted)
Cia tej yam kev mob 2-8 degree (protectfromlight)
Acidity coefficient (pKa) 7.35 ± 0.40 (Predicted)

Pob ntawm CAS:145901-11-7|6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE

25kg ua

Cov khoom no siv tau rau 24 lub hlis txij li hnub tsim khoom thaum khaws cia hauv lub xeev sov so.

Kev nyab xeeb thiab kev thauj mus los

Cov khoom no yuav tsum tau muab ntim rau hauv chav tsev kub. Cov neeg siv khoom yuav tsum ua tib zoo nyeem cov khoom kho mob, cov ntaub ntawv kev nyab xeeb cov ntaub ntawv (MSDS) thiab cov ntawv sau ua ntej siv, paub txog cov khoom lag luam cov ntaub ntawv kev nyab xeeb, cov lus qhia ua haujlwm, kev cuam tshuam ib puag ncig, thiab hnav kev tiv thaiv tus kheej tsim nyog raws li qhov xav tau. khoom siv.

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