CAS: 7724-12-1|6-Amino-2-benzothiazolecarbonitrile

Taw qhia ntawm CAS: 7724-12-1|6-Amino-2-benzothiazolecarbonitrile

Functionalized 2-cyanobenzothiazoles (CBTs), xws li ACBT, yog lub tsev tseem ceeb rau kev sib txuas ntawm luciferins . Lawv hnov ​​​​mob sai thiab xaiv nrog 1,2-aminothiols nyob rau hauv lub cev. Qhov kev xaiv thiab bioorthogonal reactivity ntawm CBTs tau raug siv los tsim CBT ligation raws li qhov muaj txiaj ntsig thiab ceev bioorthogonal cov tshuaj tiv thaiv.

6-Amino-2-cyanobenzothiazole (ACBT) yog ib qho kev sib xyaw ua ke nrog cov amine kov rau ncaj qha derivatization . Nws yog ib qho tseem ceeb hauv tsev thaiv rau kev sib txuas ntawm luciferin derivatives rau bioluminescent imaging thiab tuav rau bioorthogonal ligations. Cov mis mos ntawm ACBT yog C8H5N3S thiab nws muaj qhov hnyav molecular ntawm 175.21.

Specification of CAS: 7724-12-1|6-Amino-2-benzothiazolecarbonitrile

Kev Tshawb Fawb Daim Ntawv Thov CAS: 7724-12-1|6-Amino-2-benzothiazolecarbonitrile

Chemiluminescence thiab Medicinal Diagnostics

6-Amino-2-cyanobenzothiazole (ACBT) yog ib qho tseem ceeb precursor nyob rau hauv synthesis ntawm Firefly luciferin, ib yam khoom ntuj pom nyob rau hauv cov kab Photinus pyralis. Cov tshuaj no yog qhov tseem ceeb hauv qee qhov kev siv tau zoo tshaj plaws chemiluminescence siv niaj hnub no. Vim nws lub luag haujlwm hauv cov tshuab no, nws muaj cov ntawv thov tseem ceeb hauv kev kuaj mob, biochemistry, thiab forensic trace analysis (Würfel li al., 2012).

Bioorthogonal Ligations thiab Imaging

ACBT tau lees paub rau nws cov khoom siv hauv bioorthogonal ligations thiab ua lub tsev thaiv rau luciferin derivatives siv hauv bioluminescent duab. Nws versatility yog txhim kho los ntawm lub xub ntiag ntawm amine kov, uas tso cai rau ncaj qha derivatization. Qhov kev hloov pauv no tau siv zog hauv kev lag luam thiab kev sib txuas ua ke, ua rau ACBT muaj txiaj ntsig zoo hauv ntau yam kev tshawb fawb, tshwj xeeb hauv kev ua duab (Hauser li al., 2016).

Synthesis ntawm Heterocyclic Compounds

ACBT plays lub luag haujlwm tseem ceeb hauv kev sib txuas ntawm heterocyclic compounds, uas yog lub hauv paus tsev thaiv hauv kev tshawb fawb tshuaj, kev ua liaj ua teb, thiab kev tshawb nrhiav tshuaj. Nws ua ke nrog lwm cov tebchaw, xws li ethylacetoacetate, nyob rau hauv cov xwm txheej tshwj xeeb, tau ua rau kev tsim cov molecules nrog cov haujlwm tseem ceeb ntawm biochemical, qhia txog nws qhov tseem ceeb hauv thaj chaw ntawm hluavtaws chemistry (Padder li al., 2022).

Nanoparticle Tsim rau Cellular Imaging

Cov tshuaj tiv thaiv condensation ntawm 6-hydroxy-2-cyanobenzothiazole (ib qho cuam tshuam rau ACBT) thiab cysteine ​​tau raug siv los tsim cov nanoparticles rau cov duab ntawm tes. Cov tshuaj tiv thaiv no tsim lub hauv paus rau kev tsim cov fluorescent sojntsuam siv hauv kev tshuaj xyuas hydrolytic enzymes xws li caspase-3/7 thiab -galactosidase, ua kom pom ACBT qhov kev siv hluav taws xob hauv cov txheej txheem kev ntsuas qib siab hauv cellular thiab molecular biology (Chen li al., 2020).

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