CAS: 137145-75-6|1,4,7,10-Tetraazacyclododecane-1-acetic Acid,1,1-dimethylethyl Ester

Taw qhia ntawm CAS: 137145-75-6|1,4,7,10-Tetraazacyclododecane-1-acetic acid,1,1-dimethylethyl ester

1,4,7,10-Tetraazacyclododecane-1-acetic acid, 1,1-dimethylethyl ester, feem ntau hu ua TETA, yog ntau yam sib xyaw uas tau kawm ntau yam hauv thaj chaw ntawm chemistry thiab biochemistry. TETA yog ib qho macrocyclic ligand uas tsim kev ruaj khov nrog ntau yam hlau ions, suav nrog tooj liab, zinc, thiab npib tsib xee. Cov complexes tau pom tias muaj ntau yam kev siv hauv thaj chaw xws li catalysis, duab, thiab xa tshuaj.

Specification of CAS: 137145-75-6|1,4,7,10-Tetraazacyclododecane-1-acetic acid,1,1-dimethylethyl ester

Kev Tshawb Fawb Daim Ntawv Thov CAS: 137145-75-6|1,4,7,10-Tetraazacyclododecane-1-acetic acid,1,1-dimethylethyl ester

Chelating Agent rau Lanthanide Ions

1,4,7,10-Tetraazacyclododecane derivatives zoo li DOTA-Tris(t)Bu ester ua haujlwm ua ntej tus neeg ua haujlwm chelating rau lanthanide ions. Cov tebchaw no, thaum sau npe nrog ntau yam kev ua haujlwm moieties lossis macromolecules, txhim kho lub hom phiaj tshwj xeeb, kev xa tawm hauv lub cev, bio-compatibility, thiab pharmacokinetics ntawm qhov sib piv xov xwm siv hauv molecular imaging. Cov synthesis ntawm cov tebchaw no yog qhov tseem ceeb vim lawv cov nqi lag luam siab, txwv kev siv dav. Ib txoj hauv kev yooj yim thiab muaj txiaj ntsig zoo nrog rau tag nrho cov txiaj ntsig ntawm 92% tau tsim, muab kev xaiv siv tau ntau dua rau cov chaw soj nstuam los tsim cov khoom sib xyaw no hauv cov khoom loj ntawm tus nqi txo (Li, Winnard, & Bhujwalla, 2009).

Synthetic Routes for Metal-Coded DOTA-Based Affinity Tags

Txhim kho txoj kev hluavtaws rau cov derivatives ntawm 1,4,7,10-tetraazacyclododecane, xws li 1-benzyl-1,4,7,10-tetraazacyclododecane thiab 1,4,7,{ {12}}tetraazacyclododecane-1-acetic acid ethyl ester, tau tsim. Cov tebchaw no yog cov khoom tseem ceeb pib rau hlau-coded DOTA-raws li affinity cim npe, nrog rau kev siv nyob rau hauv ntau yam kev ntsuam xyuas biochemical thiab imaging cov tswv yim. Cov synthesis suav nrog kev npaj ntawm lanthanide complexes, ua kom pom qhov sib txawv ntawm cov khoom sib txuas hauv kev tshawb fawb (Kohl li al., 2007).

Macrocyclic-Based Phosphonate Esters rau Cell Loading

Cov compound 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid, ethyl ester) (DOTPME) tau ua daim nyias nyias permeable los ntawm kev tsim nws cov acetoxymethyl (AM ) derivative (DOTPME-AM). Qhov kev sib txuas no qhia tau hais tias DOTPME-AM tuaj yeem nkag mus rau hauv cell membranes, tau hydrolyzed los ntawm cellular esterases kom rov tsim dua DOTPME, thiab yog li ua rau hauv cov hlwb. Txoj kev no muaj peev xwm tsim cov ligands tshwj xeeb rau kev ntsuas, tsis muaj kev ntsuas ntawm ions xws li Ca2+ thiab Mg2+ los ntawm 31P NMR thev naus laus zis (Chavez, Kovács, & Sherry, 1999).

Khoom txhawb nqa Chelators rau Radiometalated Oligonucleotides

Esterified precursors ntawm 1,4,7,10-tetraazacyclododecane derivatives tau siv rau immobilizing ntawm tswj pore iav, ua kom muaj kev sib dhos ntawm oligonucleotide chains. Cov derivatives no yog qhov tseem ceeb rau kev sib txuas ntawm radiometalated oligonucleotides, uas tuaj yeem siv rau hauv vivo imaging nrog cov tswv yim zoo li positron emission tomography (PET) (Kiviniemi li al., 2012).

Synthesis ntawm Bifunctional Chelating Agents

Txoj kev loj hlob ntawm cov tshiab bifunctional chelating agents raws li 1,4,7,10-tetraazacyclododecane derivatives tau ua kom pom tseeb vim lawv ntau yam hauv kev sib txuas nrog biomolecules xws li cov proteins thiab peptides. Qhov kev sib txuas no muaj xws li macrocycle DO3A derivatized nrog aliphatic linker uas muaj cov ester nquag, uas tuaj yeem cuam tshuam nrog lub hom phiaj biomolecule. Cov chelators no muaj cov ntawv thov hauv ntau qhov chaw, suav nrog bioconjugation thiab kev xa tshuaj (Calce, Monfregola, & Luca, 2013).

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