CAS: 124011-52-5|1, 2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA ntsev

Taw qhia ntawm CAS: 124011-52-5|1, 2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA ntsev

MPEG-DSPE, los yog MPEG-Drug Substance Processing and Evaluation, yog ib lub tshuab tsim los ntawm Moving Picture Experts Group (MPEG) uas ua rau muaj kev ntsuam xyuas cov tshuaj yeeb tshuaj. Cov thev naus laus zis no tau siv dav hauv kev lag luam kws tshuaj rau kev soj ntsuam cov tshuaj yeeb tshuaj, nrog rau hauv kev sim tshuaj. Nws yog cov cuab yeej muaj zog uas tuaj yeem siv los ntsuas qhov zoo thiab kev nyab xeeb ntawm cov tshuaj yeeb tshuaj thiab muab cov ntaub ntawv tseem ceeb rau kev txhim kho tshuaj.

Specification of CAS: 124011-52-5|1, 2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA ntsev

Kev Tshawb Fawb Daim Ntawv Thov CAS: 124011-52-5|1, 2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA ntsev

MPEG-DSPE hauv Nanoparticle Imaging thiab Drug Delivery

MPEG-DSPE tau siv nyob rau hauv txoj kev loj hlob ntawm ze-infrared fluorophores rau skeletal system duab. Ib txoj kev tshawb fawb qhia txog kev siv DSPE-mPEG encapsulated lub ntiaj teb tsis tshua muaj doped nanoparticles (RENPs@DSPE-mPEG) uas qhia txog kev sib raug zoo rau cov pob txha yam tsis tau tsom ligands. Txoj hauv kev no muaj lub tswv yim tsis muaj kev cuam tshuam rau kev kos duab ntawm lub cev pob txha thiab kev kuaj mob pob txha, nrog lub peev xwm hauv kev tiv thaiv kab mob thiab mob qog noj ntshav nanoparticles (He et al., 2019).

Kev cuam tshuam rau liposomal tshuaj formulations

DSPE-mPEG, ib tsev neeg ntawm amphiphilic lipopolymers, plays lub luag haujlwm tseem ceeb hauv kev tsim cov tshuaj txhaj tshuaj, ntev-kho cov tshuaj nanoparticulate formulations. Kev tshawb fawb tau qhia nws cov txiaj ntsig hauv PEGylation ntawm lipidic nonlamellar kua crystalline hais, uas yog siv los tsim cov cubosomes thiab hexosomes rau kev siv tshuaj thiab tshuaj ntsuam xyuas kev xa khoom. Kev koom ua ke ntawm DSPE-mPEG rau hauv cov qauv no cuam tshuam rau lawv cov morphology thiab sab hauv nanostructure, txhim kho lawv lub peev xwm hauv kev xa tshuaj (Nilsson li al., 2014).

Reversible Attachment ntawm Polyethylene Glycol

Qhov rov qab txuas tau ntawm methoxypoly (ethylene glycol) (mPEG) rau cov amino-muaj substrates siv DSPE tau tshawb nrhiav. Lub tswv yim no, nrog rau kev tsim cov benzyl carbamate linkage hloov nrog ib tug disulfide, tso cai rau cov creation ntawm lipopolymers muaj peev xwm poob lawv polymer txheej nyob rau hauv tej yam kev mob. Txoj hauv kev no yog qhov tseem ceeb hauv cov ntsiab lus ntawm kev xa tshuaj, qhov uas tswj kev tso tawm thiab lub hom phiaj yog qhov tseem ceeb (Zalipsky li al., 1999).

Cell Surface Engineering

DSPE-mPEG tau raug tshawb xyuas nyob rau hauv cov ntsiab lus ntawm cell nto engineering. Nws tau raug siv los hloov kho qhov chaw ntawm tes, cuam tshuam rau ntau yam kev coj cwj pwm ntawm tes xws li kev vam meej, kev loj hlob, kev loj hlob, thiab adhesion. Txoj kev tshawb no pom tau hais tias kev hloov kho DSPE-mPEG cuam tshuam rau kev ua haujlwm ntawm tes, muab kev nkag siab rau hauv kev siv cell nto engineering hauv biomedicine (Cai li al., 2022).

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