CAS No.

Taw qhiathiab daim ntawv thovntawm CAS No.

1h-Pyrrolo[2,3-b]pyridin-5-ol yog cov tshuaj hluavtaws uas siv los ua ib qho nruab nrab hauv kev sib txuas ntawm cov tshuaj venetoclax. Nws tau pom tias yog ib qho inhibitor ntawm Bcl-2 thiab yog ib qho fluorine-muaj heterocycle. Cov tshuaj yog synthesized los ntawm reacting 2,4, 6-trifluoroacetic acid nrog 1H-pyrrole nyob rau hauv lub xub ntiag ntawm Grignard reagent thiab trimethylchlorosilane.

Cov tshuaj tiv thaiv intermediates yog tom qab ntawd lim thiab hloov mus rau hauv 1h-pyrrolo[2,3-b]pyridin-5-ol siv trifluoroacetic acid thiab hydrochloric acid. Cov impurities tuaj yeem raug tshem tawm los ntawm recrystallization lossis distillation. 1h-Pyrrolo[2,3-b]pyridin-5-ol yog industrially tsim los ntawm reacting

Synonyms:

1H-PYRROLO[2,3-B]PYRIDIN-5-OL;

Specification ntawm CAS No.

Package ua thiab kev thauj mus losntawm Kev Taw Qhia thiab kev siv ntawmCAS No.

Pob: 0.1g, 1g, 5g, 25g, 100g, 500g, 1kg

Kev thauj mus los: los ntawm courier / los ntawm huab cua / los ntawm hiav txwv

Cov ntawv txheebntawmCAS No.

Kev tshawb pom muaj zog thiab xaiv Bcl -2 inhibitors nrog acyl sulfonamide skeleton

B Wang, W Feng, J Wang, Y Dong, Y Liu, Y Yao... - Bioorganic & Medicinal ..., 2021 - Elsevier

... los ntawm pib los ntawm kev lag luam muaj tert-butyl 4-bromo-2-fluorobenzoate (7), uas yog

reacted nrog 1H-pyrrolo[2,3-b]pyridin-5-ol nyob rau hauv lub xub ntiag ntawm NaOBu-t muab intermediate 8. …

Cim npe nrov: cas no.98549-88-3 |1h-pyrrolo[2,3-b]pyridin-5-ol, China cas no.98549-88-3 |1h-pyrrolo[2,{10} }b]pyridin-5-ol manufacturers, hoobkas