Taw qhiathiab daim ntawv thovntawm CAS No. 231278-84-5|5-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino) quinazolin-6-yl)furan{{ 7}}carbaldehyde
5-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan{{ 6}}carbaldehyde yog ib qho heterocyclic compound uas tau siv los kawm txog cov protein tyrosine kinase kev ua haujlwm. Cov tshuaj no khi rau qhov chaw nquag ntawm cov enzyme thiab inhibits nws txoj haujlwm los ntawm kev tsim cov irreversible covalent daim ntawv cog lus nrog cov enzyme reactive cysteine residue, uas tiv thaiv kev hloov ntawm phosphate pawg los ntawm ATP mus rau lub substrate (tyrosine).
Lapatinib nruab nrab.
Synonyms:
CTK1A1282;
5-[4-[{2}}Chloro-4-(3-fluorobenzyloxy)anilino]-6-quinazolinyl]furan-2-carboxaldehyde;
5-(4-(4-(3-fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)furan-2-carbaldehyde;
5-(4-[{2}}chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde;
5-{4-[3-chloro-4-(3-fluorobenzyloxyl)-phenylamino]-quinazolin-6-yl}-furan-2- carbaldehyde;
AGN-PC-0D1ZTN;
5-(4-{3-chloro-4-[(3-fluorobenzyl)oxy]anilino}-6-quinazolinyl)-2-furaldehyde;
5-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan{{ 6}}carbaldehyde;
5-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl){{6 }}furaldehyde;
Specification ntawm CAS No. 231278-84-5|5-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino) quinazolin-6-yl)furan{{ 7}}carbaldehyde
|
Yam khoom |
SPECIFICATION |
|
CAS |
231278-84-5 |
|
MF |
C26H17ClFN3O3 |
|
MW |
473.88 |
|
Qhov ntom |
1.4 07 ± 0.06 g / cm3 (Tshaj tawm) |
|
Boiling point |
65 0.3 ± 55.0 degree (Predicted) |
|
Melting point |
227 0 mus rau 231 0 degree |
|
acidity coefficient (pKa) |
5.18 ± 0.30 (Tshaj tawm) |
|
Solubility |
DMSO (me ntsis), Methanol (Muaj me ntsis) |
Package ua thiab kev thauj mus losntawm Kev Taw Qhia thiab kev siv ntawmCAS No. 231278-84-5|5-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino) quinazolin-6-yl)furan{{ 7}}carbaldehyde
Pob: 0.1g, 1g, 5g, 25g, 100g, 500g, 1kg
Kev thauj mus los: los ntawm courier / los ntawm huab cua / los ntawm hiav txwv
Cov ntawv txheebntawmCAS No. 231278-84-5|5-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino) quinazolin-6-yl)furan{{ 7}}carbaldehyde
FDA pom zoo rau 6-tus tswv cuab lub nplhaib fused pyrimidine-based derivatives
S Arora, R Kumar - Fused Pyrimidine-Based Drug Discovery, 2023 - Elsevier
... Cyclic acetal ntawm 8.1.173 tau cleaved nyob rau hauv acidic mob kom tau txais 5-(4-((3-chloro-4-((3-fluorobenzyl)oxy)) phenyl)amino)quinazolin-6-yl)furan-2-carbaldehyde
Cim npe nrov: cas no.231278-84-5|5-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino) quinazolin-6-yl)furan{{ 7}}carbaldehyde, China cas no.231278-84-5|5-(4-(({11}}chloro-4-((3-fluorobenzyl)oxy)phenyl)amino) quinazolin-6-yl)furan{{ 15}}carbaldehyde manufacturers, hoobkas
