Taw qhiathiab daim ntawv thovntawm CAS No. 2152628-33-4|Selpertatinib
Selpercatinib yog ib yam tshuaj me me uas inhibits kev ua ntawm tyrosine kinases, uas yog cov enzymes uas ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm tes thiab kev sib txawv. Selpercatinib tau pom tias inhibit ntau tyrosine kinases, suav nrog RET, VEGFR-2, KIT thiab PDGFR-b. Selpercatinib tam sim no tab tom raug tshuaj xyuas rau kev kho mob ntawm cov kab mob colectal adenocarcinoma thiab hepatic impairment. Selpercatinib kuj tau pom tias muaj txiaj ntsig zoo rau cov qog nqaij hlav hauv vitro.
Cov tshuaj muaj kev sib raug zoo siab tiv thaiv x-ray siv lead ua qauv ntawm RET thiab VEGFR-2 kinase domains. Selpercatinib muaj qhov hnyav molecular thiab soluble hauv dej ntawm qhov tsis tshua muaj siab, ua rau nws yooj yim solubilized hauv aqueous buffer solutions lossis cell culture media. Kev soj ntsuam hauv vitro tau ua los txiav txim siab selpercatinib lub sijhawm ua haujlwm ntev.
Synonyms:
LOXO-292;
Specification ntawm CAS No. 2152628-33-4|Selpertatinib
|
Yam khoom |
SPECIFICATION |
|
CAS |
2152628-33-4 |
|
MF |
C29H31N7O3 |
|
MW |
525.6 |
|
Qhov ntom |
1.36 ± 0.1 g / cm3 (Tshaj tawm) |
|
solubility |
DMSO:20.0(Max Conc. mg/mL); 38.05(Max Conc. mM) |
|
acidity coefficient (pKa) |
14.00±{2}}.29 |
Package ua thiab kev thauj mus losntawm Kev Taw Qhia thiab kev siv ntawmCAS No. 2152628-33-4|Selpertatinib
Pob: 0.1g, 1g, 5g, 25g, 100g, 500g, 1kg
Kev thauj mus los: los ntawm courier / los ntawm huab cua / los ntawm hiav txwv
Cov ntawv txheebntawmCAS No. 2152628-33-4|Selpertatinib
[HTML] Selpercatinib: thawj qhov kev pom zoo
A Markham - Tshuaj, 2020 - Springer
... ntawm selpercatinib nrog ntau koob tshuaj txhua hnub ntawm omeprazole tau cuam tshuam nrog kev txo qis
selpercatinib AUC 0-INF thiab C max thaum selpercatinib … Coadministration of selpercatinib with …
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