Nqe lus piav txog CAS: 37762-06-4|ZAPRINAST
| CAS Nr | 37762-06-4 |
| EINECS Number | 253-655-1 |
| Molecular Formula | C13H13N5O2 |
| Molecular Luj | 271.27 |
| Purity | 99% |
| Pob | 25 mg 50 mg 100 mg 500 mg 1 g |
Synonyms:
2-(2-PROPYLOXYPHENYL)-8-AZAPURIN-6-IB;
B 22,948;
2-o-propoxyphenyl-8-azapurin-6-ib qho;
8-Aza-2-(2-propoxyphenyl)-6-purinone;
Potassium phosphate monobasic;
3,6-dihydro-5-(2-propoxyphenyl);
1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d ) pyrimidin-7-ib;
Phenylaza purinon;
2-(2-Propoxyphenyl)-8-azahypoxanthine;
Daim ntawv thov:
Zaprinast yog ib tus neeg sib tw kho mob tsis ua tiav uas yog tus thawj coj ntawm cov tshuaj muaj feem xyuam nrog PDE5 inhibitors, xws li sildenafil (Viagra), uas tau mus txog kev lag luam. Nws yog phosphodiesterase inhibitor, xaiv rau subtypes PDE5, PDE6, PDE9 thiab PDE11. IC50 qhov tseem ceeb yog 0.76, 0.15, 29.{13}}, thiab 12.0 μM, feem.
Zaprinast inhibits kev loj hlob ntawm asexual blood-stage malaria parasites (P. falciparum) hauv vitro nrog tus nqi ED50 ntawm 35 μM, thiab inhibits PfPDE1, P. falciparum cGMP-specific phosphodiesterase, nrog IC50 tus nqi ntawm 3.8 μM.
Zaprinast kuj tau pom tias ua kom cov menyuam ntsuag G-protein txuas nrog lub npe hu ua GPR35, ob qho tib si hauv nas thiab tib neeg - txawm li cas los xij qhov tseem ceeb ntawm qhov no tseem tsis tau txiav txim siab.
Nws yog feem ntau siv los kawm txog kev tso tawm thiab cov txheej txheem ntawm cov neurotransmitters, tshwj xeeb tshaj yog nyob rau hauv kev tshawb fawb ntawm cov leeg nqaij so, vasodilation, thiab kev kho mob ntawm obstructive pulmonary hypertension. Tsis tas li ntawd, nws tseem tuaj yeem siv los kho lwm yam kab mob xws li kab mob plawv, kab mob obstructive pulmonary thiab mob ntsws obstructive pulmonary.
Cim npe nrov: cas: 37762-06-4|zaprinast, Suav teb cas: 37762-06-4|zaprinast manufacturers, hoobkas
